                         SEQUENCE LISTING

<110>  Yim, Kalvin
       Danso, Steven
       Hausknecht, Edward C.
 
<120>  Recombinant Butyrylcholinesterases and Truncates Thereof

<130>  550730-154

<140>
<141>

<150>  61/284,444
<151>  2009-12-21

<160>  11     

<170>  PatentIn version 3.4

<210>  1
<211>  1825
<212>  DNA
<213>  Artificial

<220>
<223>  Codon Optimized Polynucleotide encoding human BChE 

<400>  1
ttaattaaga attcgccacc atggcctgcc ccggctttct gtgggccctg gtgatcagca     60
cctgtctgga attttctatg gccgaggacg acatcatcat tgccaccaag aacggcaaag    120
tgcggggcat gaacctgacc gtgttcggcg gcaccgtgac cgcttttctg ggcatccctt    180
acgcccagcc ccccctgggc cggctgagat tcaagaagcc ccagagcctg accaagtggt    240
ccgacatctg gaacgccacc aaatacgcca acagctgctg ccagaacatc gaccagagct    300
tccccggctt ccacggcagc gagatgtgga accccaacac cgacctgagc gaggactgcc    360
tgtacctgaa cgtgtggatt cccgccccta agcccaagaa cgccaccgtg ctgatctgga    420
tctacggcgg aggcttccag accggcacca gcagcctgca cgtgtacgac ggcaagttcc    480
tggccagagt ggaacgcgtg atcgtggtgt ccatgaacta cagagtgggc gccctgggct    540
tcctggctct gcccggaaat cccgaggccc ctggcaacat gggcctgttc gaccagcagc    600
tggccctgca gtgggtgcag aagaatatcg ccgccttcgg cggcaacccc aagagcgtga    660
ccctgtttgg cgagtctgcc ggcgctgcca gcgtgtccct gcatctgctg agccctggca    720
gccacagcct gttcacccgg gccatcctgc agagcggcag cttcaatgcc ccttgggccg    780
tgaccagcct gtacgaggcc cggaaccgga ccctgaacct ggccaagctg accggctgca    840
gcagagagaa cgagacagag atcatcaagt gcctgcggaa caaggacccc caggaaatcc    900
tgctgaacga ggccttcgtg gtgccctacg gcacccccct gagcgtgaac ttcggcccta    960
ccgtggacgg cgacttcctg accgacatgc ccgacatcct gctggaactg ggacagttca   1020
agaaaaccca gatcctggtg ggagtgaaca aggacgaggg aaccgccttc ctggtgtacg   1080
gcgctcccgg cttcagcaag gacaacaaca gcatcatcac ccggaaagag ttccaggaag   1140
gcctgaagat cttcttcccc ggcgtgtccg aatttggcaa agagagcatc ctgttccact   1200
acaccgactg ggtggacgac cagcggcccg agaattaccg ggaagccctg ggcgacgtgg   1260
tgggagacta caacttcatc tgccctgccc tggagttcac caagaaattc agcgagtggg   1320
gcaacaacgc cttcttctac tacttcgaac acagaagcag caagctgccc tggcctgagt   1380
ggatgggcgt gatgcacggc tacgagatcg agttcgtgtt cggcctgccc ctggaacggc   1440
gggacaacta caccaaggcc gaagagatcc tgagccggtc catcgtgaag agatgggcca   1500
acttcgccaa atacggcaac cctaacgaga cacagaacaa cagcaccagc tggcccgtgt   1560
tcaagagcac cgagcagaag tacctgaccc tgaacaccga gagcacccgg atcatgacca   1620
agctgcgggc tcagcagtgc cggttctgga cctcattctt cccaaaggtg ctggaaatga   1680
ccggcaacat cgacgaggcc gagtgggagt ggaaggccgg ctttcaccgg tggaacaact   1740
acatgatgga ctggaagaac cagttcaacg actacaccag caagaaagaa agctgcgtgg   1800
gcctgtgatg aggatccggc gcgcc                                         1825


<210>  2
<211>  595
<212>  PRT
<213>  Human

<400>  2
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      

Glu Phe Ser Met Ala Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly 
            20                  25                  30          

Lys Val Arg Gly Met Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala 
        35                  40                  45              

Phe Leu Gly Ile Pro Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe 
    50                  55                  60                  

Lys Lys Pro Gln Ser Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr 
65                  70                  75                  80  

Lys Tyr Ala Asn Ser Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly 
                85                  90                  95      

Phe His Gly Ser Glu Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp 
            100                 105                 110         

Cys Leu Tyr Leu Asn Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala 
        115                 120                 125             

Thr Val Leu Ile Trp Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser 
    130                 135                 140                 

Ser Leu His Val Tyr Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val 
145                 150                 155                 160 

Ile Val Val Ser Met Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala 
                165                 170                 175     

Leu Pro Gly Asn Pro Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln 
            180                 185                 190         

Gln Leu Ala Leu Gln Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly 
        195                 200                 205             

Asn Pro Lys Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser 
    210                 215                 220                 

Val Ser Leu His Leu Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg 
225                 230                 235                 240 

Ala Ile Leu Gln Ser Gly Ser Phe Asn Ala Pro Trp Ala Val Thr Ser 
                245                 250                 255     

Leu Tyr Glu Ala Arg Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly 
            260                 265                 270         

Cys Ser Arg Glu Asn Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys 
        275                 280                 285             

Asp Pro Gln Glu Ile Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly 
    290                 295                 300                 

Thr Pro Leu Ser Val Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu 
305                 310                 315                 320 

Thr Asp Met Pro Asp Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr 
                325                 330                 335     

Gln Ile Leu Val Gly Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Val 
            340                 345                 350         

Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg 
        355                 360                 365             

Lys Glu Phe Gln Glu Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu 
    370                 375                 380                 

Phe Gly Lys Glu Ser Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp 
385                 390                 395                 400 

Gln Arg Pro Glu Asn Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp 
                405                 410                 415     

Tyr Asn Phe Ile Cys Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu 
            420                 425                 430         

Trp Gly Asn Asn Ala Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys 
        435                 440                 445             

Leu Pro Trp Pro Glu Trp Met Gly Val Met His Gly Tyr Glu Ile Glu 
    450                 455                 460                 

Phe Val Phe Gly Leu Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala 
465                 470                 475                 480 

Glu Glu Ile Leu Ser Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala 
                485                 490                 495     

Lys Tyr Gly Asn Pro Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro 
            500                 505                 510         

Val Phe Lys Ser Thr Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser 
        515                 520                 525             

Thr Arg Ile Met Thr Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr 
    530                 535                 540                 

Ser Phe Phe Pro Lys Val Leu Glu Met Thr Gly Asn Ile Asp Glu Ala 
545                 550                 555                 560 

Glu Trp Glu Trp Lys Ala Gly Phe His Arg Trp Asn Asn Tyr Met Met 
                565                 570                 575     

Asp Trp Lys Asn Gln Phe Asn Asp Tyr Thr Ser Lys Lys Glu Ser Cys 
            580                 585                 590         

Val Gly Leu 
        595 


<210>  3
<211>  1732
<212>  DNA
<213>  Artificial

<220>
<223>  Codon Optimized Polynucleotide encoding truncated human BChE 

<400>  3
ttaattaaga attcgccacc atggcctgcc ccggctttct gtgggccctg gtgatcagca     60
cctgtctgga attttctatg gccgaggacg acatcatcat tgccaccaag aacggcaaag    120
tgcggggcat gaacctgacc gtgttcggcg gcaccgtgac cgcctttctg ggcatccctt    180
acgcccagcc ccccctgggc cggctgagat tcaagaagcc ccagagcctg accaagtggt    240
ccgacatctg gaacgccacc aaatacgcca acagctgctg ccagaacatc gaccagagct    300
tccccggctt ccacggcagc gagatgtgga accccaacac cgacctgagc gaggactgcc    360
tgtacctgaa cgtgtggatt cccgccccta agcccaagaa cgccaccgtg ctgatctgga    420
tctacggcgg aggcttccag accggcacca gcagcctgca cgtgtacgac ggcaagttcc    480
tggccagagt ggaacgcgtg atcgtggtgt ccatgaacta cagagtgggc gccctgggct    540
tcctggctct gcccggaaat cccgaggccc ctggcaacat gggcctgttc gaccagcagc    600
tggccctgca gtgggtgcag aagaatatcg ccgccttcgg cggcaacccc aagagcgtga    660
ccctgtttgg cgagtctgcc ggcgctgcca gcgtgtccct gcatctgctg agccctggca    720
gccacagcct gttcacccgg gccatcctgc agagcggcag cttcaatgcc ccttgggccg    780
tgaccagcct gtacgaggcc cggaaccgga ccctgaacct ggccaagctg accggctgca    840
gcagagagaa cgagacagag atcatcaagt gcctgcggaa caaggacccc caggaaatcc    900
tgctgaacga ggccttcgtg gtgccctacg gcacccccct gagcgtgaac ttcggcccta    960
ccgtggacgg cgacttcctg accgacatgc ccgacatcct gctggaactg ggacagttca   1020
agaaaaccca gatcctggtg ggagtgaaca aggacgaggg aaccgccttc ctggtgtacg   1080
gcgctcccgg cttcagcaag gacaacaaca gcatcatcac ccggaaagag ttccaggaag   1140
gcctgaagat cttcttcccc ggcgtgtccg aatttggcaa agagagcatc ctgttccact   1200
acaccgactg ggtggacgac cagcggcccg agaattaccg ggaagccctg ggcgacgtgg   1260
tgggagacta caacttcatc tgccctgccc tggagttcac caagaaattc agcgagtggg   1320
gcaacaacgc cttcttctac tacttcgaac acagaagcag caagctgccc tggcctgagt   1380
ggatgggcgt gatgcacggc tacgagatcg agttcgtgtt cggcctgccc ctggaacggc   1440
gggacaacta caccaaggcc gaagagatcc tgagccggtc catcgtgaag agatgggcca   1500
acttcgccaa atacggcaac cctaacgaga cacagaacaa cagcaccagc tggcccgtgt   1560
tcaagagcac cgagcagaag tacctgaccc tgaacaccga gagcacccgg atcatgacca   1620
agctgcgggc tcagcagtgc cggttctgga cctcattctt cccaaaggtg ctggaaatga   1680
ccggcaacat cgacgaggcc gagtgggagt ggtgatgagg atccggcgcg cc           1732


<210>  4
<211>  564
<212>  PRT
<213>  Artificial

<220>
<223>  Truncated human BChE Polypeptide

<400>  4
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      

Glu Phe Ser Met Ala Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly 
            20                  25                  30          

Lys Val Arg Gly Met Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala 
        35                  40                  45              

Phe Leu Gly Ile Pro Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe 
    50                  55                  60                  

Lys Lys Pro Gln Ser Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr 
65                  70                  75                  80  

Lys Tyr Ala Asn Ser Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly 
                85                  90                  95      

Phe His Gly Ser Glu Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp 
            100                 105                 110         

Cys Leu Tyr Leu Asn Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala 
        115                 120                 125             

Thr Val Leu Ile Trp Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser 
    130                 135                 140                 

Ser Leu His Val Tyr Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val 
145                 150                 155                 160 

Ile Val Val Ser Met Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala 
                165                 170                 175     

Leu Pro Gly Asn Pro Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln 
            180                 185                 190         

Gln Leu Ala Leu Gln Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly 
        195                 200                 205             

Asn Pro Lys Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser 
    210                 215                 220                 

Val Ser Leu His Leu Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg 
225                 230                 235                 240 

Ala Ile Leu Gln Ser Gly Ser Phe Asn Ala Pro Trp Ala Val Thr Ser 
                245                 250                 255     

Leu Tyr Glu Ala Arg Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly 
            260                 265                 270         

Cys Ser Arg Glu Asn Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys 
        275                 280                 285             

Asp Pro Gln Glu Ile Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly 
    290                 295                 300                 

Thr Pro Leu Ser Val Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu 
305                 310                 315                 320 

Thr Asp Met Pro Asp Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr 
                325                 330                 335     

Gln Ile Leu Val Gly Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Val 
            340                 345                 350         

Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg 
        355                 360                 365             

Lys Glu Phe Gln Glu Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu 
    370                 375                 380                 

Phe Gly Lys Glu Ser Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp 
385                 390                 395                 400 

Gln Arg Pro Glu Asn Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp 
                405                 410                 415     

Tyr Asn Phe Ile Cys Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu 
            420                 425                 430         

Trp Gly Asn Asn Ala Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys 
        435                 440                 445             

Leu Pro Trp Pro Glu Trp Met Gly Val Met His Gly Tyr Glu Ile Glu 
    450                 455                 460                 

Phe Val Phe Gly Leu Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala 
465                 470                 475                 480 

Glu Glu Ile Leu Ser Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala 
                485                 490                 495     

Lys Tyr Gly Asn Pro Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro 
            500                 505                 510         

Val Phe Lys Ser Thr Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser 
        515                 520                 525             

Thr Arg Ile Met Thr Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr 
    530                 535                 540                 

Ser Phe Phe Pro Lys Val Leu Glu Met Thr Gly Asn Ile Asp Glu Ala 
545                 550                 555                 560 

Glu Trp Glu Trp 
                

<210>  5
<211>  1773
<212>  DNA
<213>  Artificial

<220>
<223>  Polynucleotide encoding fusion of human BChE Polypeptide 
       with goat signal sequence

<400>  5
atgaaggtcc tcatccttgc ctgtctggtg gctctggccc ttgcaagaga agatgacatc     60
ataattgcaa caaagaatgg aaaagtcaga gggatgaact tgacagtttt tggtggcacg    120
gtaacagcct ttcttggaat tccctatgca cagccacctc ttggtagact tcgattcaaa    180
aagccacagt ctctgaccaa gtggtctgat atttggaatg ccacaaaata tgcaaattct    240
tgctgtcaga acatagatca aagttttcca ggcttccatg gatcagagat gtggaaccca    300
aacactgacc tcagtgaaga ctgtttatat ctaaatgtat ggattccagc acctaaacca    360
aaaaatgcca ctgtattgat atggatttat ggtggtggtt ttcaaactgg aacatcatct    420
ttacatgttt atgatggcaa gtttctggct cgggttgaaa gagttattgt agtgtcaatg    480
aactataggg tgggtgccct aggattctta gctttgccag gaaatcctga ggctccaggg    540
aacatgggtt tatttgatca acagttggct cttcagtggg ttcaaaaaaa tatagcagcc    600
tttggtggaa atcctaaaag tgtaactctc tttggagaaa gtgcaggagc agcttcagtt    660
agcctgcatt tgctttctcc tggaagccat tcattgttca ccagagccat tctgcaaagt    720
ggttccttta atgctccttg ggcggtaaca tctctttatg aagctaggaa cagaacgttg    780
aacttagcta aattgactgg ttgctctaga gagaatgaga ctgaaataat caagtgtctt    840
agaaataaag atccccaaga aattcttctg aatgaagcat ttgttgtccc ctatgggact    900
cctttgtcag taaactttgg tccgaccgtg gatggtgatt ttctcactga catgccagac    960
atattacttg aacttggaca atttaaaaaa acccagattt tggtgggtgt taataaagat   1020
gaagggacag cttttttagt ctatggtgct cctggcttca gcaaagataa caatagtatc   1080
ataactagaa aagaatttca ggaaggttta aaaatatttt ttccaggagt gagtgagttt   1140
ggaaaggaat ccatcctttt tcattacaca gactgggtag atgatcagag acctgaaaac   1200
taccgtgagg ccttgggtga tgttgttggg gattataatt tcatatgccc tgccttggag   1260
ttcaccaaga agttctcaga atggggaaat aatgcctttt tctactattt tgaacaccga   1320
tcctccaaac ttccgtggcc agaatggatg ggagtgatgc atggctatga aattgaattt   1380
gtctttggtt tacctctgga aagaagagat aattacacaa aagccgagga aattttgagt   1440
agatccatag tgaaacggtg ggcaaatttt gcaaaatatg ggaatccaaa tgagactcag   1500
aacaatagca caagctggcc tgtcttcaaa agcactgaac aaaaatatct aaccttgaat   1560
acagagtcaa caagaataat gacgaaacta cgtgctcaac aatgtcgatt ctggacatca   1620
ttttttccaa aagtcttgga aatgacagga aatattgatg aagcagaatg ggagtggaaa   1680
gcaggattcc atcgctggaa caattacatg atggactgga aaaatcaatt taacgattac   1740
actagcaaga aagaaagttg tgtgggtctc taa                                1773


<210>  6
<211>  590
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion of human BChE Polypeptide with goat signal sequence

<400>  6
Met Lys Val Leu Ile Leu Ala Cys Leu Val Ala Leu Ala Leu Ala Arg 
1               5                   10                  15      

Glu Asp Asp Ile Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met 
            20                  25                  30          

Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro 
        35                  40                  45              

Tyr Ala Gln Pro Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser 
    50                  55                  60                  

Leu Thr Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser 
65                  70                  75                  80  

Cys Cys Gln Asn Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu 
                85                  90                  95      

Met Trp Asn Pro Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn 
            100                 105                 110         

Val Trp Ile Pro Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp 
        115                 120                 125             

Ile Tyr Gly Gly Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr 
    130                 135                 140                 

Asp Gly Lys Phe Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met 
145                 150                 155                 160 

Asn Tyr Arg Val Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro 
                165                 170                 175     

Glu Ala Pro Gly Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln 
            180                 185                 190         

Trp Val Gln Lys Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val 
        195                 200                 205             

Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu 
    210                 215                 220                 

Leu Ser Pro Gly Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser 
225                 230                 235                 240 

Gly Ser Phe Asn Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg 
                245                 250                 255     

Asn Arg Thr Leu Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn 
            260                 265                 270         

Glu Thr Glu Ile Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile 
        275                 280                 285             

Leu Leu Asn Glu Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val 
    290                 295                 300                 

Asn Phe Gly Pro Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp 
305                 310                 315                 320 

Ile Leu Leu Glu Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly 
                325                 330                 335     

Val Asn Lys Asp Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly 
            340                 345                 350         

Phe Ser Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu 
        355                 360                 365             

Gly Leu Lys Ile Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser 
    370                 375                 380                 

Ile Leu Phe His Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn 
385                 390                 395                 400 

Tyr Arg Glu Ala Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys 
                405                 410                 415     

Pro Ala Leu Glu Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala 
            420                 425                 430         

Phe Phe Tyr Tyr Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu 
        435                 440                 445             

Trp Met Gly Val Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu 
    450                 455                 460                 

Pro Leu Glu Arg Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser 
465                 470                 475                 480 

Arg Ser Ile Val Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro 
                485                 490                 495     

Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr 
            500                 505                 510         


Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr 
        515                 520                 525             

Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys 
    530                 535                 540                 

Val Leu Glu Met Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys 
545                 550                 555                 560 

Ala Gly Phe His Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln 
                565                 570                 575     

Phe Asn Asp Tyr Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
            580                 585                 590 



<210>  7
<211>  595
<212>  PRT
<213>  Artificial

<220>
<223>  Oligopeptide from amino acids 565-595 of SEQ ID NO: 2

<400>  7
Lys Ala Gly Phe His Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn
1               5                   10                  15 

Gln Phe Asn Asp Tyr Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
            20                  25                  30                 


<210>  8
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Chi sequence 

<400>  8
gctggtgg										8


<210>  9
<211>  10
<212>  RNA
<213>  Artificial

<220>
<223>  Kozak sequence 

<400>  9
accaccaugg										10


<210>  10
<211>  10
<212>  RNA
<213>  Artificial

<220>
<223>  Kozak sequence 

<400>  10
gccaccaugg										10


<210>  11
<211>  7
<212>  DNA
<213>  Artificial

<220>
<223>  Transcription initiation site 

<400>  11
tataaaa										7
